Pseudoproline Dipeptides
Pseudoproline dipeptides contain oxazoles formed from serine or threonine. When treated with trifluoroacetic acid (TFA), the oxazoles are converted to serine or threonine. The oxazoles have structural similarities to proline, thus they are named pseudoprolines. Like proline, the pseudoprolines create a “kink” in the polyamide backbone of peptides. , The kink disrupts the interchain hydrogen…